CPI 444
Triazolo-pyramidine derivative
CAS: 1202402-40-1
Molecular Formula: C20H21N7O3
CPI 444 - Names and Identifiers
CPI 444 - Physico-chemical Properties
| Molecular Formula | C20H21N7O3 |
| Molar Mass | 407.43 |
| Density | 1.55±0.1 g/cm3(Predicted) |
| Melting Point | 169-171°C |
| Boling Point | 676.9±65.0 °C(Predicted) |
| Solubility | DMSO:≥ 125 mg/mL |
| Appearance | solid |
| Color | Beige |
| pKa | 4.05±0.30(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
CPI 444 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.454 ml | 12.272 ml | 24.544 ml |
| 5 mM | 0.491 ml | 2.454 ml | 4.909 ml |
| 10 mM | 0.245 ml | 1.227 ml | 2.454 ml |
| 5 mM | 0.049 ml | 0.245 ml | 0.491 ml |
Last Update：2024-01-02 23:10:35
CPI 444 - Reference Information
| application | CPI-444 is an effective selective A2A receptor (A2AR) inhibitor to induce anti-tumor response. |
| use | CPI-444 is an oral antagonist of A2A receptor, which binds to adenosine receptor on the surface of immune cells. |
| biological activity | Ciforadenant(CPI-444, V81444) is an effective selective Adenosine A2A receptor antagonist, which binds to A2AR with a Ki value of 3.54 nM, and its selectivity to A2AR is more than 50 times higher than that of other adenosine receptor subtypes. |
| target | TargetValue A2AR () 3.54 nM(Ki) |
| Target | Value |
| A2AR () | 3.54 nM(Ki) |
Last Update：2024-04-09 21:54:55
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View History
CPI 444
(4-甲基萘-1-基)甲醇
腺嘌呤二核苷酸磷酸钠
2,6-二氯-4,8-二哌啶子基嘧啶(5,4-D)并嘧啶
Trifluoperazine N-β-D-Glucuronide
METHYL 4-([(E)-(2-HYDROXY-4-METHOXYPHENYL)METHYLIDENE]AMINO)-2-METHOXYBENZENECARBOXYLATE
1-ETHYNYL-1-CYCLOOCTANOL
6-(Methoxycarbonyl)spiro[3.3]heptane-2-carboxylic acid
3-(甲氨基)丙酸甲酯
2-氟-5-羟基苯甲酸
(4-甲基萘-1-基)甲醇
腺嘌呤二核苷酸磷酸钠
2,6-二氯-4,8-二哌啶子基嘧啶(5,4-D)并嘧啶
Trifluoperazine N-β-D-Glucuronide
METHYL 4-([(E)-(2-HYDROXY-4-METHOXYPHENYL)METHYLIDENE]AMINO)-2-METHOXYBENZENECARBOXYLATE
1-ETHYNYL-1-CYCLOOCTANOL
6-(Methoxycarbonyl)spiro[3.3]heptane-2-carboxylic acid
3-(甲氨基)丙酸甲酯
2-氟-5-羟基苯甲酸